Zocor (simvastatin) is a cholesterol-lowering medication that belongs to the statin class of drugs. Simvastatin is a member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. Many Zocor lawsuits claim that Merck was aware of the severity and frequency of Zocor side effects, but failed to adequately warn consumers of these health risks. Indications. Both simvastatin and atorvastatin belong to a class of medications known as statins . Zocor contains the active drug simvastatin. OATP1B1 mediates the hepatic uptake of statins and other endogenous compounds (e.g. [ citation needed ] Simvastatin had been shown to interact with lipid-lowering transcription factor PPAR-alpha [34] and that interaction might control the neurotrophic action of the drug. simvastatin (Zocor) Drug Class: Statins Prescription: Yes Generic: Yes Preparations: Tablets of 5, 10, 20, 40, and 80 mg. It is not known whether simvastatin is excreted into human milk; however, a small amount of another drug in this class does pass into breast milk. Mitotane: (Moderate) Use caution if mitotane and simvastatin are used concomitantly, and monitor for decreased efficacy of simvastatin and a possible change in dosage requirements. Cholesterol lowering treatment is mainly based on statins eventually associated to adjunctive drugs of different class such as ezetimibe. lipid-lowering agents.

Both "good" and "bad" cholesterol are produced in your liver. Simvastatin (SIM) is a potent inhibitor of 3-hydroy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase which converts HMG CoA into mevalonate, a precursor in cholesterol synthesis. Unknown if simvastatin excreted in human milk; because a small amount of another drug in this class is excreted in human milk and because of the potential for serious adverse reactions in nursing infants, women taking simvastatin should not breastfeed

Bad cholesterol, also called LDL, is made by combining fats with proteins. Simvastatin is a specific inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early and rate limiting step in the biosynthetic pathway for cholesterol. Simvastatin is an effective serum lipid-lowering drug that can decrease low density lipoprotein (LDL) levels by up to 50%. Therapeutic class. Simvastatin lowers the level of total cholesterol and low density lipoprotein (LDL, or "bad" cholesterol) and raises high density lipoprotein (HDL, or "good" cholesterol) levels. Because statins have the potential for serious adverse reactions in nursing infants, women who require treatment with simvastatin tablets should not breastfeed their infants [see Use in Specific Populations (8.3) ] The biopharmaceutical classification system (BCS) classifies SIM as class 2 drug having low … It's used to lower cholesterol if you've been diagnosed with high blood cholesterol.It's also taken to prevent heart disease, including heart attacks and strokes.. It is used as a cholesterol-lowering and anti-cardiovascular disease drug. Zocor belongs to a class of drugs called Lipid-Lowering Agents, Statins, HMG-CoA Reductase Inhibitors. It is not known if Zocor is safe and effective in children younger than 10 years of age. It is used to treat elevated total cholesterol levels, LDL cholesterol, triglyceride, and apolipoprotein B levels in individuals diagnosed with primary hyperlipidemia or mixed dyslipidemia in cases where diet, lifestyle changes, or other medications are not completely lowering lipid levels. Pharmacologic class. Simvastatin drug usage statistics for the United States (2008 - 2018). What is the generic name of Simvastatin? with drugs in the statin drug class, including atorvastatin and simvastatin (Zocor) with fenofibrate The only FDA-approved dosage of Zetia is 10 mg once a day. 17 Terms. Drug Name Generic Name : simvastatin Brand Name: Apo-Simvastatin (CAN), Gen-Simvastatin (CAN), CO Simvastatin (CAN), Novo-Simvastatin (CAN), ratio-Simvastatin (CAN), Zocor Classification: Antihyperlipidemic, HMG-CoA reductase inhibitor Pregnancy Category X Dosage & Route Available forms : Tablets—5, 10, 20, 40, 80 mg ADULTS Initially, 20 mg PO; up to 80 mg PO daily in the evening. Zocor Class Action Litigation. It's thought that simvastatin (Zocor) may be more likely to cause muscle pain as a side effect than other statins when it's taken at high doses. In the present review, we analysed the pharmacokinetics, efficacy and safety of ezetimibe + simvastatin drug association. bilirubin) for subsequent elimination. Statins are a class of prescription drugs used together with diet and exercise to reduce blood levels of low-density lipoprotein (LDL) cholesterol ("bad cholesterol"). daily dose 10 mg and pack size of 28 tablets; treatment should form part of a programme to reduce risk of coronary heart disease. Atorvastatin and simvastatin (Lipitor vs Zocor) Simvastatin is the drug of statins lass that goes under the brand name Zocor and the atorvastatin is another drug from the class of statins and it undergoes by the name of the Lipitor. Simvastatin is a prodrug and is hydrolyzed to its active -hydroxyacid form, simvastatin acid, after administration. The simvastatin component of Vytorin is in a drug class called statins. Simvastatin, a prodrug, is converted to its active metabolite simvastatin acid (SVA), which is a substrate of the organic anion transporter protein OATP1B1. Lipid-lowering agent. Simvastatin belongs to a group of medicines called statins.. What drug class is simvastatin? Atorvastatin (Lipitor) and simvastatin (Zocor) belong to a class of medications known as statins, which are considered to be first-choice medications for treating high cholesterol. It lowers the level of cholesterol and triglycerides in the blood. In patients taking simvastatin 80 mg for whom an interacting agent is needed, a lower dose of simvastatin or an alternative statin-based regimen with less potential for drug-drug interactions should be used (see Section 4.2 Dose and Method of Administration; Section 4.3 Contraindications). Approximately 78 % and also 11 % of the administered radioactivity were recovered in the feces and also pee, specifically, over a 10-day collection period. chloe_curdy. It is not known whether simvastatin is excreted into human milk; however, a small amount of another drug in this class does pass into breast milk. Statins are a group of drugs that lower cholesterol levels. Simvastatin works by blocking an enzyme that helps create cholesterol in the body.

An enzyme called HMG-CoA reductase makes this happen. CHD Initially, 20 mg once daily at bedtime, may increase at 4-wk intervals to max 80 mg/day.Hyperlipidemia 10-20 mg once daily at bedtime. Zocor may cause serious side effects including: loss of appetite, upper-right side stomach pain, tiredness, itching, Zocor (simvastatin) is a lipid-lowering broker that is derived synthetically from a fermentation devices of Aspergillus terreus. What are possible side effects of Zocor? hmg coa reductase inhibitors You can register for free for limited further access, or subscribe now for full access to all our content. Areas covered: The bio-equivalence of ez … The consumption of simvastatin 10 mg in FDC has declined, whereas that of simvastatin 20 mg has increased.6 Ezetimibe 10 mg and simvastatin 20 mg are suitable for high-intensity use in high-risk groups.29 These drugs lower the LDL-C level more effectively in combination than as monotherapy.30 31 However, when ezetimibe is combined with simvastatin, the cost may increase. Because statins have the potential for serious adverse reactions in nursing infants, women who require treatment with simvastatin tablets should not breastfeed their infants [see Use in Specific Populations (8.3) ] . Statistics include drug synonyms and therapeutic classes, including: Simvastatin, Flolipid, Zocor, HMG-CoA Reductase Inhibitor. Adverse reactions may occur with both drugs, and are generally dose-related for both. It's possible, although unlikely, that one particular statin may cause side effects for you while another statin won't. As a result, less cholesterol is made and levels of cholesterol in the blood decrease. SIMVASTATIN (SIM va stat in) is known as a HMG-CoA reductase inhibitor or 'statin'. Switch to another statin drug. Simvastatin (Zocor) Sometimes, a statin is combined with another heart medication. This means that both atorvastatin and simvastatin are effective for high cholesterol and work similarly. Zocor. What is the drug class of Simvastatin? Lipitor contains the active drug atorvastatin. This drug may also reduce the risk of heart attack, stroke, or other health problems in patients with risk factors for heart or blood vessel disease. But if the drug helped lower your cholesterol, you'll likely need to stay on it long term to keep your cholesterol down. 10–15 % risk of major event in 10 years), max. Coadministration of mifepristone and simvastatin increased simvastatin and simvastatin acid exposure by 10.4-fold and 15.7-fold, respectively, in drug interaction studies. On this page about Simvastatin (AN) you will find information relating to side effects, age restrictions, food interactions, whether the medicine is available at a government subsidised price on the pharmaceutical benefits scheme (PBS) as well as other useful information. In a case filed in Missouri during 2004, a man by the named Tommy Foster alleged that Zocor … Simvastatin: High cholesterol is a medical issue that can lead to a number of debilitating diseases. Homozygous familial hypercholesterolemia 40 mg once daily at bedtime or 80 mg/day in 3 divided doses (20, 20 & 40 mg in the morning, afternoon & evening).Renal insufficiency 5-10 mg. Both simvastatin and pravastatin belong to the same class of cholesterol-lowering drug. Generic: simvastatin Trade: Zocor. Action. Drug Class: Statins To continue enjoying this content, please sign in. Some side effects that have been reported include gastrointestinal side effects, muscle effects and liver toxicity. Lipitor vs, Zocor comparison will help us understand which drug among them is the best choice for you. Simvastatin 10 mg tablets can be sold to the public to reduce risk of first coronary event in individuals at moderate risk of coronary heart disease (approx.

simvastatin drug class

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