Talk to your doctor or pharmacist if you have any questions or concerns. Major Food Interaction Grapefruit juice can significantly increase the blood levels of simvastatin. Alectinib. It is important to know if you need to avoid any Food, Herbs, or Alcohol when taking Atorvastatin. Increased plasma concentrations resulting to increased risk of myopathy and rhabdomyolysis with grapefruit juice. Drug interaction with any of these substances may enhance or decrease the effect of Atorvastatin. Food-drug interactions: effect of capsaicin on the pharmacokinetics of simvastatin and its active metabolite in rats. Severity of interaction: Severe Evidence … Amiodarone. Food interaction warning. Are Statin Side Effects 'All in Your Head'? In March 2012, the U.S. Food and Drug Administration (FDA) updated its guidance for statin users to address reports of memory loss, liver damage, increased blood sugar, development of type 2 diabetes, and muscle injury. Avoid combinations; the risk of the interaction outweighs the benefit. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Food-drug interactions: effect of capsaicin on the pharmacokinetics of simvastatin and its active metabolite in rats. Consumer information for this interaction is not currently available. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Minimally clinically significant. Simvastatin oral tablet can interact with other medications, vitamins, or herbs you may be taking. GENERALLY AVOID: Coadministration with grapefruit juice may significantly increase the plasma concentrations of lovastatin and simvastatin and their active acid metabolites. Check out the following foods to eat (and avoid) for lower cholesterol numbers and a cleaner bill of health. Drug interactions are reported among people who take Simvastatin and Flecainide acetate. CAP (3, 8 or 25 mg/kg), ketoconazole, dexamethasone or 5% CMC-Na was … Simvastatin and niacin combination is used together with a proper diet to lower cholesterol and triglyceride (fat) levels in the blood. Simvastatin, sold under the brand name Zocor among others, is a lipid-lowering medication. Major Food Interaction Grapefruit juice can significantly increase the blood levels of simvastatin. For non-prescription products, read the label or package ingredients carefully. It is also used in the treatment of long-term complications such as heart disease or stroke. There are 263 drug interactions with simvastatin. By Amy Norton. 18 years experience Cardiology. Food Interactions With Simvastatin (Zocor) Food interactions include grapefruit juice and alcohol. For example, if a 20-mg dose is administered, only 1 mg reaches the systemic circulation. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Clinical pharmacology and therapeutics. A proper diet and regular exercise should be maintained along with taking this medicine. Common interactions include gastrooesophageal reflux disease among females and fatigue among males. MONDAY, Oct. 17, 2016 (HealthDay News) -- Cholesterol-lowering statins can interact with other drugs prescribed for … This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. It is important to know if you need to avoid any Food, Herbs, or Alcohol when taking Rosuvastatin. Simvastatin does not have a clinically significant pharmacokinetic interaction with fenofibrate in humans. There are 2 alcohol/food/lifestyle interactions with simvastatin which include: Simvastatin may cause liver problems and using it with substantial quantities of ethanol may increase that risk. Administration of a single 20 mg dose of simvastatin with 8 ounces of single-strength grapefruit juice increased the AUC of simvastatin and simvastatin acid by 1.9-fold and 1.3-fold, respectively. Food-drug interactions: effect of capsaicin on the pharmacokinetics of simvastatin and its active metabolite in rats Food Chem Toxicol. It is recommended that you avoid taking Simvastatin with large amounts of grapefruit juice. Amiodarone increases the risk of rhabdomyolysis when given with simvastatin. Eat like a Mediterranean. Background: Soluble fiber supplements are recommended to reduce levels of low-density lipoprotein cholesterol (LDL-C). [citation needed] In 2006, Merck & Co's sitagliptin was approved by the FDA for treatment of diabetes mellitus type 2.The patent for simvastatin expired in 2006 and many companies began to create a generic product of simvastatin. All rights reserved. In March 2012, the U.S. Food and Drug Administration (FDA) updated its guidance for statin users to address reports of memory loss, liver damage, increased blood sugar, development of type 2 diabetes, and muscle injury. Simvastatin: Belongs to the class of HMG CoA reductase inhibitors. A member asked: heart concerns history of afib....bp is 120 over 75. no pain. Grapefruit juice can significantly increase the blood levels of simvastatin. Author information: (1)Department of Pharmacy, Union Hospital, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China. Grapefruit juice-simvastatin interaction : Effect on serum concentrations of simvastatin, simvastatin acid, and HMG-CoA reductase inhibitors Author LILJA, J. J; KIVISTÖ, K. T; NEUVONEN, P. J Department of Clinical Pharmacology, University of Helsinki, and Helsinki University Central Hospital, Finland Source. You should avoid the consumption of grapefruit or grapefruit juice during treatment with simvastatin. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Should I avoid certain foods while taking Niacin-Simvastatin Tablet, Extended Release Multiphase 24 Hr (Tablet, ER Hr)? Very Important. Before taking simvastatin, tell your doctor about all of your medical conditions. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Chlorzoxazone: (Moderate) One case report has noted a possible drug interaction between simvastatin and chlorzoxazone. For non-prescription products, read the label or package ingredients carefully. Grapefruit and grapefruit juice may interact with simvastatin and lead to potentially dangerous effects, including muscle injury. A proper diet and regular exercise should be maintained along with taking this medicine. Amiodarone. You should limit the use of alcohol while being treated with these medications. simvastatin ↔ food. Food-drug interactions: effect of capsaicin on the pharmacokinetics of simvastatin and its active metabolite in rats Food Chem Toxicol. GENERALLY AVOID: Coadministration with grapefruit juice may significantly increase the plasma concentrations of lovastatin and simvastatin and their active acid metabolites. Continue to follow the cholesterol-reducing diet recommended by your health care provider. Drug interaction with any of these substances may enhance or decrease the effect of Atorvastatin. Used in the treatment of hyperlipidemia., ... Food Interaction . This medicine may help prevent medical problems caused by clogged blood vessels, such as heart attacks and strokes. Drug interactions are reported among people who take Simvastatin and Flecainide acetate. Zocor (simvastatin) is a statin drug that lowers total cholesterol, LDL cholesterol (bad cholesterol), and triglycerides, and boosts HDL cholesterol (good cholesterol). Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). It is important to tell your doctor about all other medications you use, including vitamins and herbs. The interaction has also been reported with lovastatin, which has a similar metabolic profile to simvastatin. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Back to Top. but pulse dropped into the high 40s about 4 hours ago and is still hovering between 48 and 52. taking 120 mg of diltiazem every morning. Select one or more newsletters to continue. Rosuvastatin, pitavastatin, and simvastatin are not affected by food, whereas fluvastatin, pravastatin, and atorvastatin have a reduced absorption with food. Manufacturer advises adjust simvastatin dose. April 1, 2020 Update: The Food and Drug Administration (FDA) announced the recall of all medications containing the ingredient ranitidine, known by the brand name Zantac. 2013 Mar;53:168-73. doi: 10.1016/j.fct.2012.11.045. Zetia, atorvastatin, Jardiance, Brilinta, fenofibrate, Lopid, Xarelto, rosuvastatin, Lipitor, Crestor. Does Simvastatin Interact with other Medications? Notes for Consumers: Simvastatin (Zocor) may be taken with or without food. Simvastatin Food Interactions. Both simvastatin and alcohol can increase the risk of hepatotoxicity. Shake the liquid for at least 20 seconds before you measure a dose. Simvastatin Interactions with Food and Herbs Grapefruit Juice: Grapefruit juice increases the concentration of simvastatin in the blood stream leading to possible side effects. also tal. It is recommended that you avoid taking Simvastatin with large amounts of grapefruit juice. the maximum recommended dose for simvastatin in conjunction with amlodipine or diltiazem is now 20 mg/day A full updated listing of all the interactions is provided in the table below. May enhance hepatic side hepatic effects with alcohol. Selected from data included with permission and copyrighted by First Databank, Inc. Drug interaction with any of these substances may enhance or decrease the effect of Rosuvastatin. It is important to know if you need to avoid any Food, Herbs, or Alcohol when taking Rosuvastatin. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. It is important to know if you need to avoid any Food, Herbs, or Alcohol when taking Atorvastatin. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Both simvastatin and alectinib can increase the risk of hepatotoxicity. Take simvastatin oral suspension (liquid) on an empty stomach. 2 of 10. Severity of interaction: Severe Evidence … Back to Top. Other Interactions . Moderately clinically significant. Major Food Interaction Consumer information for this interaction is not currently available. The study is created by eHealthMe based on reports of 271 people who take Simvastatin and Flecainide acetate from the FDA, and is updated regularly. Drug interaction with any of these substances may enhance or decrease the effect of Rosuvastatin. Action . Detailed recommendations for dose restrictions when used with some other drugs as interactions may increase the risk of adverse effects, or reduce the effectiveness of statin treatment. Common side effects of Zocor include headache, nausea, vomiting, diarrhea, abdominal pain, muscle pain, abnormal liver tests, hypersensitivity reactions, memory loss, forgetfulness, amnesia, confusion, and memory impairment. This can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue. Do not stop using any medications without first talking to your doctor. Other Interactions . Both simvastatin and alcohol can increase the risk of hepatotoxicity. 6.Li S, Yu Y, Jin Z, Dai Y, Lin H, Jiao Z, Ma G, Cai W, Han B, Xiang X. Simvastatin is used to reduce the level of bad cholesterol in the body. Using alcohol or tobacco with certain medicines may also cause interactions to occur. simvastatin ↔ food. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. 1. Major Food Interaction. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. In some cases, rhabdomyolysis can cause kidney damage and even death. Promptly consult your doctor or pharmacist. You should also seek immediate medical attention if you develop fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. A change in your diet, medicine, or dosage may be necessary. Simvastatin has the following interaction information: Alcohol. Amiodarone increases the risk of rhabdomyolysis when given with simvastatin. Common side effects of Zocor include headache, nausea, vomiting, diarrhea, abdominal pain, muscle pain, abnormal liver tests, hypersensitivity reactions, memory loss, forgetfulness, amnesia, confusion, and memory impairment. This study attempted to investigate the effect of CAP on the pharmacokinetics of simvastatin (SV), a cytochrome P450 (CYP) 3A substrate and an important cholesterol-lowering agent. Food Interactions With Simvastatin (Zocor) Food interactions include grapefruit juice and alcohol. Sergey Yechikov/Shutterstock. Find everything you need to know about Zocor (Simvastatin), including what it is used for, warnings, reviews, side effects, and interactions. Available for Android and iOS devices. An interaction is when a substance changes the way a … Grapefruit juice inhibits CYP3A4 and should be given the same consideration as the above drug classes. Simvastatin is usually taken in the evening or at bedtime. Background: Soluble fiber supplements are recommended to reduce levels of low-density lipoprotein cholesterol (LDL-C). Simvastatin is used to reduce the level of bad cholesterol in the body. Zhai XJ(1), Chen JG, Liu JM, Shi F, Lu YN. It is also used in the treatment of long-term complications such as heart disease or stroke. simvastatin is now contraindicated with ciclosporin, danazol and gemfibrozil the maximum recommended dose for simvastatin in conjunction with amlodipine or diltiazem is now 20 mg/day A … This can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue. Promptly consult your doctor or pharmacist. Simvastatin and niacin work together to treat cholesterol and lipid (fat) disorders. Consuming alcohol with statins increases your chances of developing liver toxicity, and statins should be avoided altogether if you have alcoholic hepatitis. Avoid grapefruit unless MD instructs otherwise. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. One of the unique properties of simvastatin is very low bioavailability (<5%) due to high firstpass metabolism. WebMD does not provide medical advice, diagnosis or treatment. Continue to follow the cholesterol-reducing diet recommended by your health care provider. In 1991, Merck & Co's simvastatin was approved as an HMG-COA inhibitor to lower the levels of LDL cholesterol. It is important to know if you need to avoid any Food, Herbs, or Alcohol when taking Ezetimibe. In some cases, rhabdomyolysis can cause kidney damage and even death. 40 mg of zocor at night and half an aspirian. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts. Drug interactions are reported among people who take Simvastatin and Coq10. What you should do about this interaction: While you are taking this medicine, do not eat grapefruit or drink grapefruit juice at any time. Let your doctor know immediately if you have unexplained muscle pain, tenderness, or weakness during treatment, especially if these symptoms are accompanied by fever or dark colored urine. Simvastatin, sold under the brand name Zocor among others, is a lipid-lowering medication. Major Food Interaction. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Usually avoid combinations; use it only under special circumstances. Simvastatin has the following interaction information: Alcohol. We evaluated the LDL-C-lowering effect of psyllium husk added to low-dose simvastatin therapy. We comply with the HONcode standard for trustworthy health information -. The FDA also advised against taking OTC forms of ranitidine, and for patients taking prescription ranitidine to speak with their healthcare provider about other treatment options before stopping medication. Consumer information for this interaction is not currently available. There are 6 disease interactions with simvastatin which include: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Zocor (simvastatin) is a statin drug that lowers total cholesterol, LDL cholesterol (bad cholesterol), and triglycerides, and boosts HDL cholesterol (good cholesterol). Do not stop using any medications without first talking to your doctor. Although all statins may be affected by drug interactions, simvastatin is exceptionally sensitive for several reasons. Drug interaction with any of these substances may enhance or decrease the effect of Ezetimibe. Things to remember when you fill your prescription. Common interactions include abdominal symptom among females and palpitations among males. Common interactions include abdominal symptom among females and palpitations among males. In some cases, rhabdomyolysis can cause kidney damage and even death. Epub 2012 Dec 5. How Long Does Coronavirus Live On Surfaces? Manufacturer advises adjust simvastatin dose. GENERALLY AVOID: Coadministration with grapefruit juice may significantly increase the plasma concentrations of lovastatin and simvastatin and their active acid metabolites. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. History. Should I avoid certain foods while taking Simvastatin? Avoid grapefruit juice while taking simvastatin. Sign Up to Receive Our Free Coroanvirus Newsletter. This can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue. Combo 'Polypill' May Cut Heart Attack, Stroke Risk Up to 40%, Computer 'Nudge' Spurs Doctors to Prescribe Statins to Heart Patients. © 2005 - 2019 WebMD LLC. Provides a summary of interactions with vitamins, herbs, and food https://www.webmd.com/drugs/2/drug-6105/simvastatin-oral/details Grapefruit juice can increase simvastatin levels in your body and increase the risk of side effects. Notes for Consumers: Simvastatin (Zocor) may be taken with or without food. Grapefruit juice inhibits CYP3A4 and should be given the same consideration as the above drug classes. You may need to take simvastatin on a long-term basis. A change in your diet, medicine, or dosage may be necessary. Highly clinically significant. J Clin Pharmacol 2004 Sep;44(9):1054-62. Very Important. Food–drug interactions: Effect of capsaicin on the pharmacokinetics of simvastatin and its active metabolite in rats Author links open overlay panel Xue-jia Zhai a Jian-guo Chen b Jin-mei Liu a Fang Shi a Yong-ning Lu a Call your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. Author information: (1)Department of Pharmacy, Union Hospital, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China. Major Food Interaction Consumer information for this interaction is not currently available. simvastatin diltiazem interaction. The study is created by eHealthMe based on reports of 271 people who take Simvastatin and Flecainide acetate from the FDA, and is updated regularly. WebMD provides information about interactions between Simvastatin Oral and avoid-grapefruit-unless-md-instructs-otherwise. Discuss the use of grapefruit products with your doctor. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. When consumed with food, lovastatin is more efficiently absorbed. Severe Interactions. We evaluated the LDL-C-lowering effect of psyllium husk added to low-dose simvastatin therapy. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Dr. Joan Woo answered. Find everything you need to know about Zocor (Simvastatin), including what it is used for, warnings, reviews, side effects, and interactions. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Alectinib. Zhai XJ(1), Chen JG, Liu JM, Shi F, Lu YN. A change in your diet, medicine, or dosage may be necessary. HealthDay Reporter. Inform MD. Both simvastatin and alectinib can increase the risk of hepatotoxicity. Simvastatin is a sensitive CYP3A4 substrate and ceritinib is a strong CYP3A4 inhibitor. The study is created by eHealthMe based on reports of 669 people who take Simvastatin and Coq10 from the FDA, and is updated regularly. These medications are not usually taken together. GENERALLY AVOID: Coadministration with grapefruit juice may significantly increase the plasma concentrations of lovastatin and simvastatin and their active acid metabolites.

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